Curaçao Criteria for HHT

The Curaçao Criteria are a set of diagnostic criteria for Hereditary Hemorrhagic Telangiectasia (also known as Osler-Weber-Rendu Syndrome).¹
1. Epistaxis: Spontaneous and recurrent epistaxis.
2. Telangiectasias: Multiple telangiectasias at characteristic sites including the lips, oral cavity, fingers, and nose.
3. Visceral lesions: including gastrointestinal telangiectasias, pulmonary AVMs, hepatic AVMs, cerebral AVMs, or spinal AVMs.
4. Family History: a first-degree relative with HHT meeting these criteria.
Definite HHT requires 3 or more of the above criteria.
Suspected/possible HHT requires 2 of the above.
HHT is unlikely if less than 2 criteria are met.
Easy to remember as the name HHT already gives you 3 of the 4 criteria (Hereditary = family history, Hemorrhagic = epistaxis, Telangiectasias).

Criteria	Description
Epistaxis	Spontaneous and recurrent epistaxis
Telangiectasias	Multiple telangiectasias at characteristic sites (such as the lips, oral cavity, nose, and fingers)
Visceral lesions	Arteriovenous malformations (pulmonary, hepatic, cerebral, or spinal), or gastrointestinal telangiectasias
Family history	A first degree relative with HHT according to these criteria

Shovlin, Claire L., et al. “Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu‐Osler‐Weber syndrome).” American journal of medical genetics 91.1 (2000): 66-67. ↩

Last updated September 27, 2022