Glossary of Terms in Otolaryngology

Mikulicz Cells

  • Mikulicz cells are large vacuolated histiocytes that are classically seen in the granulomatous stage of Rhinoscleroma.1
  • The causative organism of rhinoscleroma is Klebsiella rhinoscleromatis.
  • 3 clinical stages of Rhinoscleroma:
    1. Catarrhal stage (also known as atrophic)
    2. Granulomatous stage (also known as hypertrophic)
    3. Fibrotic stage (also known as sclerotic or cicatrical).

Mikulicz Cells in Rhinoscleroma

  1. Hoffmann, E O et al. “The Mikulicz cell in rhinoscleroma. Light, fluorescent and electron microscopic studies.” The American journal of pathology vol. 73,1 (1973): 47-58. ↩

Last updated October 01, 2022
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